（41~45) Researchers have found that drugs used to treat human seizures can delay aging in
(41~45) Researchers have found that drugs used to treat human seizures can delay aging in worms by as much as 50 percent. The roundworms used for the study are similar to humans in their molecular makeup, raising the
possibility that the drugs could also extend the life span of humans。
第41题：“By finding a class of drugs that delays aging we have found a relationship between the function of the nervous system and aging that was not well understood, ” said Kerry Komfeld, a geneticist at the Washington University School of Medicine in St. Louis, Missouri. The findings are detailed this week in the journal Science。 The discovery came out of the thesis work by one of Komfeld’s graduate students, Kimberley Evason. About four years ago, Evason began exposing groups of the roundworm Caenorhabditis elegans to commercially available drugs to see if the drugs would delay aging or promote longevity。
A. But Komfeld said scientists will not know about the applicability of the drugs in humans until a similar study is done on humans. “What’s very encouraging is that these drugs were developed to treat humans, and they are well understood, because they’ve been used for a long time, ” he said。
B. Later the scientists discovered that two related anticonvulsant drugs also lengthened the lives of the worms-in the case of one drug, by almost 50 percent. “This was a big surprise to use, Komfeld said. ”“We didn’t think anticonvulsant drugs had any particular relationship to aging. That connection was completely unexpected. ”
C. Roundworms are a poor subject for experiments, because they are not like humans, even though their molecules are similar. For example, they have no bones, nor do they show emotions, making it difficult to know how exactly human subjects would react to these drugs in large quantities. However, using the worms allows experiments to be conducted quickly, because they do not live for long。
D. “Somehow the neural activity seems to regulate the aging of all of the body the skin, musculature, and reproductive tract, ” Kornfeld said. “Somehow the nervous system coordinates the progress of all these tissues, evidently, though the life stages. But we don’t know how it does that. ”
E. The discovery may also shed light on the little-understood aging process. Since the drugs act on the neuromuscular systems of both humans and worms, the findings hint at a link between neural activity and aging。
F. Unlike vertebrates, the worms are ideal subjects for the study of aging because of their short life spans, which last only a couple of weeks in a laboratory. The worm is well known in genetics, and the worm’s genome has been sequenced。
G. Use of this drug has been permitted by law since 1998 and wider use is now expected as a result of the studies. “We can clearly link this drug with human aging, but we still need to find proof, says Kornfeld optimistically. ”
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