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提问人:网友chxjcj 发布时间:2022-01-07
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根据以下材料,回答题Cancer Drug Trials Often Halted EarlyAn increasing number of clinical t

根据以下材料,回答题

Cancer Drug Trials Often Halted Early

An increasing number of clinical trials for new cancer treatments are being halted before the risks and benefits have been fully evaluated, say Italian researchers, who warn that this growing trend could put patients at risk of harm from new therapies rushed into use.

The researchers looked at 25 randomized, controlled clinical trials that were stopped early because the treatments had started to show benefit to patients.

"When we analyzed 25 trials over a 10-year period between 1997 and 2007, we found a consistent increase in prematurely stopped trials——more than 50 percent were stopped within the last three years," study co-author Giovanni Apolone said at a news conference Tuesday.

Of 14 trials halted early and published between 2005 and 2007, the researchers found that 11(79 percent) of them were used to support drug approval applications submitted to the European Medicines Agency and the U.S. Food and Drug Administration.

"This suggests a strong commercial component in stopping trials prematurely. In fact, this strategy could guarantee quicker access to the market for companies. On the other hand, a quicker clinical drug development may lead to an "immature" benefit/risk balance of new drugs,"Apolone said.

He and his colleagues "are aware that trials stopped early because they are showing benefit may result in identification of promising new treatments for patients. However, findings obtained following this strategy should be considered to be preliminary results that require subsequent confmnation."

It can take several years for the long-term benefits or harmful side effects of a new treatment to become apparent, Apolone noted, but the average duration (持续时间) of the 25 studies he and his colleagues analyzed was 30 months, with a range from 12 to 64 months.

They also found that at the time five of the studies were stopped, they"d enrolled less than 40 percent of the total number of patients planned for final analysis.

"Clinical trials need to stop early for superior benefit whenever there"s proof beyond reasonable doubt that the new treatment really is superior. That would be an ethical obligation,"Stuart Pocock, a professor of medical statistics at the London School of Hygiene and Tropical Medicine in the United Kingdom, said at the news conference. "However, too many trials are stopped early claiming efficacy (功效) without strong evidence being available."

The number of prematurely stopped clinical trials has increased recently. 查看材料

A.Right

B.Wrong

C.Not mentioned

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更多“根据以下材料,回答题Cancer Drug Trials Often Halted EarlyAn increasing number of clinical t”相关的问题
第1题
根据以下材料,回答题Study Confirms Red Meat Link with Bowed (结肠) CancerPeople who eat mor

根据以下材料,回答题

Study Confirms Red Meat Link with Bowed (结肠) Cancer

People who eat more than 160 grams of red or processed meat a day are 35 percent more likely to develop bowel cancer than those who eat less 51______ 20 grams a day, according to one of the biggest nutrition investigations ever carried out.

The European Prospective Investigation into Cancer and Nutrition followed 478,040 men and women 52______ 35 to 70 from 10 European countries.

All subjects were free of cancer at enrollment between 1992 and 1998, but 53______ an average follow-up of almost 5 years 1,329 bowel cancers had been reported.

The subsequent analysis, published in the Journal of the National Cancer Institute, confirms the long-held suspicion 54______ high intakes (纳入量) of red meat are associated with increased bowel 55______ risk.

After taking into consideration factors like age, sex, height, weight, energy intake physical activity,smoking, and alcohol consumption, the investigators found that bowel cancer was 56______ with intake of red and processed meat but not chicken.

Risk of bowel cancer dropped with increasing intake of fish. Eating more than 80 grams a day of fish was associated 57______ a 31 percent reduction in risk compared with eating less than 10 grams a 58______

Subjects with high red meat and low fish intake were at 63 percent higher" risk of bowel cancer compared with subjects with low red meat and high fish 59______ . In addition, the risk of developing the disease was increased for 60______ people who ate a low fibre diet.

Sheila Bingham, study investigator at the UK"s Medical Research Council nutrition unit, said:

"People have suspected for some time that high levels of red and processed meat 61______ risk of bowel cancer, but this is one of the largest studies worldwide and the first from Europe of this type to show a 62 ______relationship."

She added in a statement: "the overall picture is very consistent for red and processed meat and fibre across all the 63______ populations studied."

Study coordinator, Elio Riboli, of the World Health Organisation International Agency for Research into Cancer, said: "Other risk factors for 64______ cancer include obesity (肥胖) and lack of physical activity. Smoking and excess alcohol may also play a 65______. These factors were all taken into account in the analysis.

回答(51)题 查看材料

A.from

B.than

C.between

D.among

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第2题
根据以下材料,回答题Studies Show US Spending Doesn"t Get Best HealthThe United States may s

根据以下材料,回答题

Studies Show US Spending Doesn"t Get Best Health

The United States may spend twice as much on health care as other rich countries, but it is not getting results to match according to studies released on Tuesday.

But in the study of five wealthy countries, published in the journal Health Affairs, researchers found no single nation had clearly the worst or best health care system.

Gerard Anderson at Johns Hopkins University"s school of public health and colleagues came up with a list of 21 health fields they could evenly compare across the five countries ——Australia,Canada, Britain, New Zealand and the United States.

"Hone of the five countries is consistently the best or the worst on all 21 indicators." Anderson said during a telephone briefing for reporters.

"If you are looking for the place to get the best care, there isn"t a single place. Every country has at least one indicator where it scores the best of the five countries and each country has at least one indicator where it scores the worst of the five countries. "

But, he said, the United States is not getting value for money. "The United States should be particularly concerned about these results, given that we spend twice as much on health care as any other country. So spending more doesn"t necessarily result in "better outcomes."

Anderson"s group of international health experts sponsored by the Commonwealth Fund spent five years working on the study, getting the latest possible data from the five countries on areas such as breast cancer and leukemia survival, suicide rates, death rates from asthma, vaccination rates and cancer screening.

The US spends twice as much on health care as other rich countries. 查看材料

A.Right

B.Wrong

C.Not mentioned

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第3题
根据以下材料,回答题Breaking the News about Your Diagnosis(1) When I was diagnosed with bre

根据以下材料,回答题

Breaking the News about Your Diagnosis

(1) When I was diagnosed with breast cancer nearly a year ago, I found myself at a loss for words at first. Over time, however, I developed some pointers (点子 ), which I hope will help others.

(2) During the first few weeks of emotional "aftershocks" (余悸) from the diagnosis, I found myself unable to utter the word "cancer". Still, I wanted to share the news with my relatives and friends who already knew that I"d had a biopsy (活检) and were anxiously awaiting my telephone call. I did the best 1 could, which is all anyone can do in this situation. When I called them, I said, "What we feared has happened." They immediately knew what I meant.

(3) Nearly a year after my diagnosis, I find myself more comfortable telling people "I was diagnosed with cancer" instead of saying "I have cancer." On some deep level, I don"t want to "own" this illness. Choose language that suits you when you share your news. And keep in mind that there is no one "right" way of doing this.

(4) Most people, after hearing your announcement, will be curious about the next step. They may wonder if you will be undergoing radiation therapy and/or chemotherapy(化疗). They may wonder where and when you will have surgery. Answer their questions as best you can, but keep in mind that "I don"t know right now" or "I"m still in too much shock to think about that" are good answers.

(5) Wait until the initial wave of strong emotions has passed before telling the children in your life. Don"t overwhelm (使不知所措) very young children with too much information. Assure them that, even if you will be in the hospital for a while, they will see you every day and they will be cared for. Older children may already fear the word "cancer", so be prepared to reassure them. Emphasize the positive steps that doctors will be taking to treat your illness.

Paragraph 2__________. 查看材料

A.Break the news as calmly as possible to children

B.Break the news at your own pace

C.Share the good news with your friends

D.Choose language that suits you

E.Follow your doctor"s advice

F.Be prepared for people"s curiosity

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第4题
根据以下材料,回答题Screen Test(1) Every year millions of women are screened with X-rays to

根据以下材料,回答题

Screen Test

(1) Every year millions of women are screened with X-rays to pick up signs of breast cancer. If this happens early cough, the disease can often be treated successfully. According to a survey published last year,21 countries have screening programmes. Nine of them, including Australia, Canada, the US and Spain, screen women under 50.

(2) But the medical benefit of screening these younger women are controversial, partly because the radiation brings a small risk of inducing cancer. Also, younger women must be given higher doses of X-rays because their breast tissue is denser.

(3) Researchers at the Polytechnic University1 of Valencia analysed the effect of screening more than 160,000 women at 11 local clinics. After estimating the women"s increasing dose of radiation, they used two models to calculate the number of extra cancers this would cause.

(4) The mathematical model recommended by Britain"s National Radiological Protection Board(NRPB) predicted that the screening programme would cause 36 cancers per 100,000 women,18 of them fatal. The model preferred by the UN Scientific Committee on the Effects of Atomic Radiation led, to a lower figure of 20 cancers.

(5) The researchers argue that the level of radiation-induced cancers is "not very significant"compared to the far larger number of cancers that are discovered and treated. The Valencia programme, they say, detects between 300 and 450 cases of breast cancer in every 100,000 women screened.

(6) But they point out that the risk of women contracting cancer from radiation could be reduced by between 40 and 80 percent if screening began at 50 instead of 45, because they would be exposed to less radiation. The results of their study, they suggest, could help "optimise (完善)the technique" for breast cancer screening.

(7) "There is a trade-off (平衡) between the diagnostic benefits of breast screening and its risks."admits Michael Clark of the NRPB. But he warns that the study should be interpreted with caution. "On the basis of the current data, for every 10 cancers successfully detected and prevented there is a risk of causing one later in life. That"s why radiation exposure should be minimised in any screening programme."

Paragraph 2 ___________ 查看材料

A.Harm Screening May Do to a Younger Woman

B.Small Risk of Inducing Cancers from Radiation Models

C.Investigating the Effect of Screening

D.Effects Predicted by Two Different

E.Treatment of Cancers

F.Factors That Trigger Cancers

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第5题
根据以下材料,回答题Brain-dead Mother Dies after Giving BirthA brain-dead woman who was kep

根据以下材料,回答题

Brain-dead Mother Dies after Giving Birth

A brain-dead woman who was kept alive for three months so she could deliver the child she was carrying was removed from life support on Wednesday and died, a day after giving birth.

"This is obviously a bittersweet time for our family," Justin Torres, the woman"s brother-in-law, said in a statement.

Susan Tortes, a cancer-stricken, 26-year-old researcher at the National Institutes of Health, suffered a stroke in May after the melanoma (黑瘤 ) spread to her brain.

Her family decided to keep her alive to give her foetus (胎儿) a chance. It became a race between the foetus" development and the cancer that was destroying the woman"s body.

Doctors said that Torres" health was getting worse and that the risk of harm to the foetus finally outweighed the benefits of extending the pregnancy.

Torres gave birth to a daughter by Caesarean section (剖腹产手术) on Tuesday at Virginia Hospital Center. The baby was two months premature and weighed about a kilogram. She was in the newborn intensive care unit.

Dr Donna Tilden-Archer, the hospital"s director of neonatology (新生儿学) , described the child as "very vigorous." She said the baby had responded when she received stimulation,indicating she was healthy.

Doctors removed Torres from life support early Wednesday with the consent of her husband,Jason Tortes, after she received the final sacrament (圣礼) of the Roman Catholic Church.

"We thank all of those who prayed and provided support for Susan, the baby and our family,"Jason Torres said in a statement. "We especially thank God for giving us little Susan. My wife"s courage will never be forgotten."

English-language medical literature contains at least 11 cases since 1979 of irreversibly brain-damaged women whose lives were prolonged for the benefit of the developing foetus,according to the University of Connecticut Health Center.

Dr Christopher McManus, who coordinated care l"or Susan Torres, put the infant"s chances of developing cancer at less than 25 per cent. He said 19 women who have had the same aggressive form. of melanoma as Tortes have given birth, and five of their babies became ill with the disease.

Susan Torres died soon after__________. 查看材料

A.she suffered a stroke

B.she became brain-dead

C.she was diagnosed with cancer

D.she gave birth to a baby

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第6题
根据下面材料,回答题。 Survey Finds Many Women Misinformed about Cancer63 percent of Ameri

根据下面材料,回答题。

Survey Finds Many Women Misinformed about Cancer

63 percent of American women think that if there&39;s no family history of cancer, you&39;re not likely to develop the disease, a new survey found.

In fact, most people who develop cancer have no family history of cancer. According to the American College of Obstetricians and Gynecologists (ACOG) (美国妇产科医师学会) , which sponsored the survey.

"Too many women are dying from cancer," Dr. Douglas W. Laube, ACOG&39;s immediate past president, said during a Friday teleconference. "An estimated 200,070 women will die in the U. S.this year, and over 600,078 women will be diagnosed with cancer. The results of this survey found a worrisome (令人担忧的) gap in women&39;s knowledge about cancer."

Based on the findings, ACOG is increasing its efforts to educate women about cancer and the need for regular screening tests.

Although the survey found many misconceptions (错误观念) about cancer,76 percent of women surveyed did say they feel knowledgeable about how they can reduce their risk of the disease.

However, only 52 percent said they were doing enough to reduce that risk. And 10 percent said they hadn&39;t done anything in the past year to lower their risk.17 percent said they wouldn&39;t change their lifestyles, even if changes would lower their cancer risk.

Many women said they were afraid to undergo screening out of fear of finding cancer.20 percent said they didn&39;t want to know if they had cancer.

In response to these findings, ACOG will launch on Oct.29 a new website, Protect&Detect:

What Women Should Know about Cancer. The guide is designed to help women to take charge of their health and improve their understanding of their risk of cancer, and the lifestyle. steps they can take to cut that risk.

Many American women have apoor knowledge of cancer. 查看材料

A.Right

B.Wrong

C.Not mentioned

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第7题
根据下面材料,回答题。What Should I Say to the Person Who Has Cancer?It is normal to feel th

根据下面材料,回答题。

What Should I Say to the Person Who Has Cancer?

It is normal to feel that you don"t know what to say to someone who has cancer. You might only know the person casually, or you may have worked ____51____ or lived near each other for many years and have a closer relationship The most important ____52____ you can do is to acknowledge the situation in some way-whatever is most comfortable for you. You can show interest and concern,you can express encouragement, or you ____53____ offer support. Sometimes the simplest expressions of concern are the ____54____ meaningful.

While it is good to be encouraging, it is also important ____55____ to show false optimism or to tell the person with cancer to always have a positive attitude. Doing____ 56____ things may discount their fears, concems, or sad feelings. It is also tempting to say that you know ____57____ the person feels. While you may know this is a difficult time, no one can know exactly how the person with ____58____ feels.

Humor can be an important way ____59____ coping. It is also another source of support and encouragement. Let the person with cancer ____60____ the lead; it is healthy if they find something funny about a side effect, like hair loss or increased appetite, and you can certainly join ____61____ in a good laugh. This can be a great way to relieve stress and to take a break from the ____62____ serious nature of the situation.

When the person with cancer looks good, let them know! Refrain (忍住) ____63____ comments when their appearance isn"t as good, such as "You"re looking pale," or "You"ve lost weight." Cancer and its treatment can be very unpredictable. Be prepared for good days and bad ____64.____

Refrain from telling the person with cancer stories about family members or friends who have had cancer. Everyone is different, and these stories may not be helpful. Instead, it is better simply to tell them you know ____65____ about cancer because you"ve been through it with someone else.

___________ 查看材料

A.hard

B.together

C.often

D.once

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第8题
请根据短文的内容,回答题。 U. S. Blacks Hard-hit by CancerDeath rates for cancer are fallin

请根据短文的内容,回答题。

U. S. Blacks Hard-hit by Cancer

Death rates for cancer are falling for all Americans, but black Americans are still more likely to die of cancer than whites, the American Cancer Society said Monday.<br>

In a special report on cancer and blacks, the organization said blacks are usually diagnosed with cancer later than whites, and they are more likely to die of the disease. This could be because of unequal (不平等的) access to medical care, because blacks are more likely to have other diseases as well, and perhaps because of differences in the biology (生物学) of the cancer itself, the report added.<br>

"In general, black Americans have less hope of surviving five years after diagnosis than whites for all cancer sites and all stages of diagnosis," the report said.<br>

"In describing cancer statistics for black Americans, this report recognizes that many of the differences associated with race may be caused by unfair social and economic differences and unequal access to medical care."<br>

The cancer society said blacks should be encouraged to get check-ups (体格检查) earlier,when cancer is more treatable, and it said more research is needed to see if biological differences play a role.<br>

"The new statistics emphasize the continuing importance of wiping out these unfair social differences through public policy and education efforts," the organization said in a statement.<br>

But it also noted a drop in cancer death rates.<br>

"Cancer death rates in both sexes for all sites combined have dropped greatly among black Americans since 1992, as have incidence rates (发生率) ," said the report.<

Black Americans arc more likely to die of cancer than__________. 查看材料

A.people in other countries

B.white Americans

C.all other Americans

D.their ancestors

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第9题
请根据短文内容,回答题。 Exercise Cuts Cancer Deaths in MenMen who exercise often are less

请根据短文内容,回答题。

Exercise Cuts Cancer Deaths in Men

Men who exercise often are less likely to die from cancer than those who __________ (51),new research published in the British Journal of Cancer revealed yesterday.

A team of scientists from the Karolinska Institute in Sweden looked __________ (52) the effect of physical activity and cancer risk in 40,708 men __________ (53) between 45 and 79.

The seven-year study found that men __________ (54) walked or cycled for at least 30 minutes a day had a 34 per cent lower risk of __________ (55)fi&39;om cancer than the men who did less exercise or nothing at all. __________ (56)the period studied,3,714 men developed cancer and 1,153 died from the disease.

The researchers suggest that half an hour&39;s walking __________ (57) cycling a day increased survival among these men by 33 percent.

The researchers surveyed men from two counties in central Sweden about their lifestyle. and the amount of __________ (58) activity they were usually doing. They then scored these responses and compared the results __________ (59) data on cancer diagnosis and death officially recorded in a central cancer registry over a seven-year period.

Lead author, Professor Alicja Wolk, said: "These results clearly show for the first time the effect that very simple and basic daily __________ (60) such as walking or cycling has in reducing cancer death risk in middle-aged and elderly __________ (61)."

Dr Lesley Walker, director of cancer information at Cancer Research UK, said: "This study gives us a clear indication that men who exercise are less __________ (62)to die from cancer, and that they are more likely to __________ (63)the disease if they get it. It&39;s not entirely clear from this study What role exercise plays in preventing __________ (64)in men, but we do know that a healthy lifestyle. can prevent up to half of all cancers-and __________ (65) exercise forms a key part of this."

__________ 查看材料

A.don"t

B.didn"t

C.won"t

D.can"t

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第10题
请根据短文内容,回答题。 Cigars Instead?Smoking one or two cigars a day doubles the risk o

请根据短文内容,回答题。

Cigars Instead?

Smoking one or two cigars a day doubles the risk of cancers of the lip, tongue, mouth, and throat, according to a government study.

Daily cigars also increase the risk of lung cancer and cancer of the esophagus, and increase the risk of cancer of the larynx (voice-box) six-fold, say researchers at the National Cancer Institute in Bethesda, Maryland.

In addition, the report revealed that smoking three or four cigars a day increased the risk of oral cancer to 8.5 times the risk for nonsmokers and the risk of esophageal cancer by four times the risk of nonsmokers.

The health effects of smoking cigars is one of eight sections of the article "Cigars: Health Effects and Trends." The researchers report that, compared with a cigarette, a large cigar emits up to 90 times as much carcinogenic tobacco-specific nitrosamines.

"This article provides clear and invaluable information about the disturbing increase in cigar use and the significant public health consequences for the country," said Dr. Richard Klausner,director of the National Cancer Institute, in a statement.

"The data are clear -- the harmful substances and carcinogens in cigar smoke, like cigarettes, are associated with the increased risks of several kinds of cancers as well as heart and lung diseases," he added. "In other words, cigars are not safe alternatives to cigarettes and may be addictive."

"To those individuals who may be thinking about smoking cigars, our advice is -- don&39;t. To those currently smoking cigars, quitting is the only way to eliminate completely the cancer, heart and lung disease risks," warned Klausner.

According to National Cancer Institute press release, there haven&39;t been any studies on the health effects on nonsmokers at cigar social events, but "...a significant body of evidence clearly demonstrates and increased lung cancer risk from secondhand smoke."

According to the report, smoking three or four cigars a day __________. 查看材料

A.increases the risk of oral cancer for non-smokers

B.greatly increases the risk of oral cancer for smokers

C.increases the risk of more than one cancer for non-smokers

D.greatly increases the risk of more than one cancer for smokers

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