nuclear protein （核蛋白)

亲核蛋白(karyophilic protein)

A.在细胞核中Ran-GTP被转变成Ran-GDP，回到细胞质同时释放importin b

B.Importin a负责识别核质蛋白的NLS，形成转运复合物；importin b能够介导核孔复合体与胞质纤维结合。

C.中央栓核孔复合体构象改变完成转运复合物的输入转运

D.在细胞核中，转运复合体与Ran-GTP结合，作用importin b 使其与复合物脱离，释放亲核蛋白

Mobile Phone and Diseases

A study by scientists in Finland has found that mobile phone radiation can cause changes in human cells that might affect the brain, the leader of the research team said,

But Darius Leszczynski, who headed the 2-year study and will present findings next week at a conference in Quebec(魁北克), said more research was needed to determine the seriousness of the changes and their impact on the brain or the body.

The study at Finland’s Radiation and Nuclear Safety Authority found that exposure to radiation from mobile phones can cause increased activity in hundreds of proteins in human cells grown in a laboratory, he said.

“We know that there is some biological response. We can detect it with our very sensitive approaches, but we do not know whether it can have any physiological effects on the human brain or human body,” Leszczynski said.

Nonetheless the study, the initial findings of which were published last month in the scientific journal Differentiation, raises new questions about whether mobile phone radiation can weaken the brain’s protective shield against harmful substances.

The study focused on changes in cells that line blood vessels and on whether such changes could weaken the functioning of the blood-brain barrier, which prevents potentially harmful substances from entering the brain from the bloodstream, Leszczynski said.

The study found that a protein called hsp27 linked to the functioning of the blood-brain barrier showed increased activity due to irradiation and pointed to a possibility that such activity could make the shield more permeable(能透过的), he said.

“Increased protein activity might cause cells to shrink—not the blood vessels but the cells themselves—and then tiny gaps could appear between those cells through which some molecules could pass.” he said.

Leszczynski declined to speculate on what kind of health risks that could pose, but said a French study indicated that headache, fatigue and sleep disorders could result.

“These are not life-threatening problems but can cause a lot of discomfort,” he said, adding that a Swedish group had also suggested a possible link with Alzheimer’s disease.

“Where the truth is do not know,” he said.

Leszczynski said that he, his wife and children use mobile phones, and he said that he did not think his study suggested any need for new restrictions on mobile phone use.

According to Leszczynski, how does mobile phone affect one’s health？ ______

A．Mobile phone radiation can increase protein activities and such activities can make the protective shield more permeable.

B．Mobile phone radiation can shrink the blood vessels and prevent blood from flowing smoothly.

C．Mobile phone radiation will bring stress to people exposed to it.

D．Mobile phone radiation kills blood cells at a rapid speed.

But Darius Leszczynski, who headed the 2-year study and will present findings next week at a conference in Quebec (魁北克), said more research was needed to determine the seriousness of the changes and their impact on the brain or the body.

The study at Finland's Radiation and Nuclear Safety Authority found that exposure to radiation from mobile phones can cause increased activity in hundreds of proteins in human cells grown in a laboratory, he said.

"We know that there is some biological response. We can detect it with our very sensitive approaches, but we do not know whether it can have any physiological effects on the human brain or human body," Leszczynski said.

Nonetheless, the study, the initial findings of which were published last month in the scientific journal Differentiation, raises new questions about whether mobile phone radiation can weaken the brain's protective shield against harmful substances.

The Study focused on changes in cells that line blood vessels and on whether such changes could weaken the functioning of the blood-brain barrier, which prevents potentially harmful substances from entering the brain from the bloodstream, Leszczynski said.

The study found that a protein called hsp27 linked to the functioning of the blood-brain barrier showed increased activity due to irradiation and pointed to a possibility that such activity could make the shield more permeable(能透过的), he said.

"Increased protein activity might cause cells to shrink—not the blood vessels but the cells themselves—and then tiny gaps could appear between those cells through which some molecules could pass," he said.

Leszczynski declined to speculate on what kind of health risks that could pose, but said a French study indicated that headache, fatigue and sleep disorders could result.

"These are not life-threatening problems but can cause a lot of discomfort," he said, adding that a Swedish group had also suggested a possible link with Alzheimer's disease.

"Where the truth is, I do not know," he said.

Leszczynski said that he, his wife and children use mobile phones', and he said that he did not think his study suggested any need for new restrictions on mobile phone use.

According to Leszczynski, how does a mobile phone affect one's health？

A．Mobile phone radiation can increase protein activities and such activities can make the brain's protective shield more permeable.

B．Mobile phone radiation can shrink the blood vessels and prevent blood from flowing smoothly.

C．Mobile phone radiation will bring stress to people exposed to it.

D．Mobile phone radiation kills blood cells.

Part A

Directions: Read the following four texts. Answer the questions below each text by choosing A, B, C or D . Mark your answers on ANSWER SHEET 1.

A study by scientists in Finland has found that mobile phone radiation can cause changes in human ceils that might affect the brain, the leader of the research team said.

But Darius Leszczynski, who headed the g-year study and will present findings next week at a conference in Quebec(魁北克), said more research was needed to determine the seriousness of the changes and their impact on the brain or the body.

The study at Finland's Radiation and Nuclear Safety Authority found that exposure to radiation from mobile phones can cause increased activity in hundreds of proteins in human cells grown in a laboratory, he said.

"We know that there is some biological response. We can detect it with our very sensitive approaches, but we do not know whether it can have any physiological effects on the human brain or human body," Leszczynski said.

Nonetheless the study, the initial findings of which were published last month in the scientific journal Differentiation, raises new questions about whether mobile phone radiation can weaken the brain's protective shield against harmful substances.

The study focused on changes in cells that line blood vessels and on whether such changes could weaken the functioning of the blood-brain barrier, which prevents potentially harmful substances from entering the brain from the bloodstream, Leszczynski said.

The study found that a protein called hsp27 linked to the functioning of the blood-brain barrier showed increased activity due to irradiation and pointed to a possibility that such activity could make the shield more permeable(能透过的), he said.

"Increased protein activity might cause cells to shrink—not the blood vessels but the cells themselves—and then tiny gaps could appear between those cells through which some molecules could pass." he said.

Leszezynski declined to speculate on what kind of health risks that could pose, but said a French study indicated that headache, fatigue and sleep disorders could result.

"These are not life-threatening problems but can cause a lot of discomfort," he said, adding that a Swedish group had also suggested a possible link with Alzheimer's disease.

"Where the truth is I do not know," he said.

Leszezynski said that he, his wife and children use mobile phones, and he said that he did not think his study suggested any need for new restrictions on mobile phone use.

According to Leszezynski, how does mobile phone affect one's health？

A．Mobile phone radiation can increase protein activities and such activities can make the protective shield more permeable.

B．Mobile phone radiation can shrink the blood vessels and prevent blood from flowing smoothly.

C．Mobile phone radiation will bring stress to people exposed to it.

D．Mobile phone radiation kills blood cells at a rapid speed.

蛋白质测序(protein sequencing)