Which of the following is an example of an epigenetic change in eukaryotes?
A、a loss of an AT base pair from a gene
B、the addition of methyl groups to cytosines in the promoter region of a gene
C、the substitution of an AT base pair by a GC base pair in a gene as a result of a mistake during DNA replication
D、a deletion that simultaneously removes two genes from the genome
E、None of these examples represents epigenetic changes.